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The primary efficacy endpoint was the change from baseline in HbA1c after 20 weeks of therapy

Therefore, when employing KD for the treatment of kidney disease, it is essential to monitor the concentration of ketones in blood or urine to prevent the onset of ketoacidosis

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Front Endocrinol (Lausanne) (2023) 14:1217165

Additionally, simpler in vivo models such as Caenorhabditis elegans provide a practical compromise for early-stage evaluation, thanks to their genetic tractability, short lifecycle, and suitability for high-throughput testing (Torre et al., 2019)